Advantages of Whole Genome Sequencing | Learn About Your DNA Data
January 31, 2019

Advantages of Whole Genome Sequencing

Advantages of Whole Genome Sequencing | Learn About Your DNA Data

In a recent article, we discussed whole genome sequencing and how it works. In this article, we are going to discuss the advantages and disadvantages of whole genome sequencing, and offer some practical advice for overcoming the disadvantages.

In a recent article, we discussed whole genome sequencing and how it works. In this article, we are going to discuss the advantages and disadvantages of whole genome sequencing, and offer some practical advice for overcoming the disadvantages.

 

The Advantages of Whole Genome Sequencing

Human whole genome sequencing (WGS) is starting to usher in a new era of personalized medicine. By allowing the entire genome of a person to be sequenced, every gene can be turned into digital data for analysis.

While this results in a large amount of data, it also results in big opportunities. Once a person has this data, it can be analyzed to easily determine if they carry genes for particular single genetic disorders like cystic fibrosis or sickle cell anemia.

But it doesn't end there. With advances in technology, WGS findings are starting to guide treatments for common cancers (colorectal cancer and melanoma) and are also being used to determine which medications are safe (and which are not) on a person-by-person basis.

 

Why is Whole Genome Sequencing So Powerful?

When compared with partial autosomal DNA technologies, such as microarray-based autosomal DNA testing, WGS provides 3,000 times more information due to the fact that it provides data on all six billion base pairs of the human genome.

Similar to partial autosomal tests, exome sequencing is another technique that also only covers a portion of the genome. It focuses on just the protein-coding sequences, which represents only 1% of the genome.

When compared with WGS, exome sequencing is again no match as WGS provides complete coverage of the coding and noncoding regions of the genome, which allows a more comprehensive assessment of genome.

WGS also offers a better determination of copy number variations, rearrangements and other structural variations due to it taking advantage of reads longer than 2×100 paired. The results of all of this is a much more thorough analysis that can offer significantly more predictive potential. However, there are disadvantages too.

 

The Disadvantages of Whole Genome Sequencing

While WGS is getting easier, faster, and less expensive for consumers, there are still some practical challenges regarding the interpretation of the data. Since most of the genetic variants in the human genome are still not fully understood, and since many diseases involve multiple genes, not all diseases can be predicted.

Because of this, we built a simple app we call Data Viewer that can help you easily explore the association between your genetic data and diseases, conditions, traits, and medication reactions. It is continually updated as the newest scientific research becomes available, so it is an excellent way to keep up to date with the latest scientific findings.

Also, most physicians are not well trained in interpreting genetic data and so many are unwilling to work with their patients DNA results. We recognize this is still a major hurdle for many people when trying to understand their results, which is why we offer a Genetic Counseling app. The app allows you to discuss your DNA results with a trained professional so you can get the kind of guidance you need to make smart decisions.

Finally, storage and analysis can also be particularly challenging since a WGS generates such a large amount of data. But here again, Sequencing.com has you covered. We offer free data storage, no matter how big your data file, and we have multiple DNA upload methods to handle any size file.

So go on, get your genome sequenced from Dante Labs, our preferred sequencing provider, and start outsmarting your genes!

Categories:
Tags:
Information and help guide for how to Upload 23andMe Data to Sequencing.com including automatically download, upload and import 23andMe data using our automatic data importer that is private, secure, confidential and encrypted. Quick, easy to use and free, the importer automatically obtains and imports DNA data from 23andMe.
September 18, 2018
If the recent 23andMe API changes may impact your DNA app and you are scared of losing access to genetic data, Sequencing.com might be able to help. While we can not provide you the same third-party apps and results, we can offer you a DNA app store you can turn to to analyze your DNA with other great third party tools.
Sequencing.com Hopes to Shepherd Growing Market of DIY Genomics Tools
September 27, 2016
Sequencing.com, a new company hoping to play a unique role in the future of personal genomics, announced its global launch last week. The last few years have seen the emergence and propagation of companies that help users in possession of their own genetic data to access and understand what this information means for their health...
DNA Testing for Fitness and Nutrition | Genome Analysis Apps
November 20, 2018
DNA testing for fitness and nutrition works like any other genetic test. Your DNA is analyzed to look for genes that factor into fitness and nutrition. But how do you do this? One way is to take a specific genetic test that provides fitness and nutrition results, but if you didn't, and you have DNA data, you can also obtain...